Development of a Robust
Protocol for the Determination
of Weak Acids’ pKa Values in DMSO

Podlech, Joachim

Development of a Robust Protocol for the Determination of Weak Acids’ pK_a Values in DMSO

Posted on 2020-07-31 - 17:34

Two methods for the determination of pK_a values of weak acids are described, a direct titration with dimsyl potassium in the presence of an indicator and a back-titration in which an analyte/indicator mixture is deprotonated and then titrated with ammonium chloride. Both methods have been validated by measuring pK_a values of compounds, for which values had been determined previously. The back-titration method was applied to measure pK_a values of two 1,3-dithiane-derived bissulfoxides and a monosulfone.

CITE THIS COLLECTION

Jung, Sebastian T.; Podlech, Joachim (2020). Development of a Robust Protocol for the Determination of Weak Acids’ pK_a Values in DMSO. ACS Publications. Collection. https://doi.org/10.1021/acs.joc.0c00909

https://doi.org/10.1021/acs.joc.0c00909

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