Design of Synthetic Polymer Nanoparticles Specifically
Capturing Indole, a Small Toxic Molecule
Version 2 2019-03-15, 13:08
Version 1 2019-03-15, 13:04
Posted on 2019-03-15 - 13:08
Synthetic
polymers are of interest as stable and cost-effective
biomolecule-affinity reagents, since these polymers interact with
target biomolecules both in vitro and in the bloodstream.
However, little has been reported about orally administered polymers
capable of capturing a target molecule and inhibiting its intestinal
absorption. Here, we describe the design of synthetic polymer nanoparticles
(NPs) specifically capturing indole, a major factor exacerbating chronic
kidney disease, in the intestine. N-isopropylacrylamide-based
NPs were prepared with various hydrophobic monomers. The amounts of
indole captured by NPs depended on the structures and feed ratios
of the hydrophobic monomers and the polymer density but not on the
particle size. The combination of hydrophobic and quadrupole interaction
was effective to enhance the affinity and specificity of NPs for indole.
The optimized NPs specifically inhibited intestinal absorption of
orally administered indole in mice. These results showed the potential
of synthetic polymer NPs for inhibiting the intestinal absorption
of a target molecule.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Okishima, Anna; Koide, Hiroyuki; Hoshino, Yu; Egami, Hiromichi; Hamashima, Yoshitaka; Oku, Naoto; et al. (2019). Design of Synthetic Polymer Nanoparticles Specifically
Capturing Indole, a Small Toxic Molecule. ACS Publications. Collection. https://doi.org/10.1021/acs.biomac.8b01820
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
Read the peer-reviewed publication
AUTHORS (7)
AO
Anna Okishima
HK
Hiroyuki Koide
YH
Yu Hoshino
HE
Hiromichi Egami
YH
Yoshitaka Hamashima
NO
Naoto Oku
TA
Tomohiro Asai