Degradable Supramolecular Photodynamic Polymer Materials
for Biofilm Elimination
Posted on 2019-06-27 - 13:34
In this work, we
fabricated a degradable supramolecular photodynamic
polymer (SPP) with an enhanced efficiency of biofilm elimination.
The small-molecule photosensitizer, a cationic porphyrin derivative,
was grafted to a block polymer backbone (BPB) through a host–guest
interaction and metal coordination. The locally enriched cationic
photosensitizer in SPP endows a high efficiency to disrupt biofilms
due to the generated reactive oxygen species (ROS) around the bacteria
under white light illumination, while reducing the cytotoxicity to
mammalian cells. After cucurbit[7]uril was added as a competitive
agent, the photosensitizer could be disassociated from the BPB and
the antibacterial ability was reduced; also the SPP could be further
degraded. As a consequence, the supramolecular photodynamic polymer
may become a very promising material for biofilm elimination with
an enhanced antibacterial efficacy and degradability to fight against
drug-resistant bacteria.
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Chen, Linghui; Yang, Yuchong; Zhang, Pengbo; Wang, Shu; Xu, Jiang-Fei; Zhang, Xi (2019). Degradable Supramolecular Photodynamic Polymer Materials
for Biofilm Elimination. ACS Publications. Collection. https://doi.org/10.1021/acsabm.9b00284
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AUTHORS (6)
LC
Linghui Chen
YY
Yuchong Yang
PZ
Pengbo Zhang
SW
Shu Wang
JX
Jiang-Fei Xu
XZ
Xi Zhang