De Novo Asymmetric Synthesis of
Homoadenosine via a
Palladium-Catalyzed N-Glycosylation

O'Doherty, George A.

De Novo Asymmetric Synthesis of Homoadenosine via a Palladium-Catalyzed N-Glycosylation

Posted on 2006-01-19 - 00:00

A highly stereoselective synthesis of l-2-deoxy-β-ribo-hexopyranosyl nucleosides from 6-chloropurine and Boc-protected pyranone has been developed. Our approach relies on the iterative application of a palladium-catalyzed N-glycosylation, diastereoselective reduction, and reductive 1,3-transposition. This strategy is amenable to prepare various natural and unnatural hexopyranosyl nucleosides analogues.

CITE THIS COLLECTION

DataCite

3 Biotech

3D Printing in Medicine

3D Research

3D-Printed Materials and Systems

4OR

AAPG Bulletin

AAPS Open

AAPS PharmSciTech

Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg

ABI Technik (German)

Academic Medicine

Academic Pediatrics

Academic Psychiatry

Academic Questions

Academy of Management Discoveries

Academy of Management Journal

Academy of Management Learning and Education

Academy of Management Perspectives

Academy of Management Proceedings

Academy of Management Review

Guppi, Sanjeeva R.; Zhou, Maoquan; O'Doherty, George A. (2016). De Novo Asymmetric Synthesis of Homoadenosine via a Palladium-Catalyzed N-Glycosylation. ACS Publications. Collection. https://doi.org/10.1021/ol052664p

https://doi.org/10.1021/ol052664p

or

Select your citation style and then place your mouse over the citation text to select it.