Curcumin and Salsalate Suppresses Colonic Inflammation
and Procarcinogenic Signaling in High-Fat-Fed, Azoxymethane-Treated
Mice
Version 2 2017-08-11, 17:53
Version 1 2017-08-11, 17:48
Posted on 2017-08-11 - 17:53
High-fat diets (HFDs) and excess
adiposity increase proinflammatory
cytokines in the colon, altering gene expression in a manner that
promotes the development of colorectal cancer (CRC). Thus, compounds
that reduce this biochemical inflammation are potential chemopreventive
agents. Curcumin (CUR), a dietary polyphenol, and salsalate (SAL),
a non-steroidal anti-inflammatory drug, are both anti-inflammatories.
We investigated the inhibitory effects of CUR with or without SAL
on inflammatory cytokines and procarcinogenic signaling in azoxymethane
(AOM)-treated A/J mice. A sub-tumorigenic AOM dose was chosen to produce
a biochemical and molecular procarcinogenic colonic environment without
tumors. Mice were fed either a HFD (60% of kilocalories) or low-fat
diet (LFD) (10% of kilocalories). One HFD treatment group received
0.2% CUR in the diet; one received 0.2% CUR + 0.15% SAL; and one received
0.4% CUR + 0.3% SAL. The HFD mice developed 30% greater fat mass than
the LFD mice (p < 0.05). The colonic concentrations
of interleukin-1β (IL-1β) and interleukin-6 (IL-6) in
the HFD mice were decreased by 50–69% by the high-dose combination
regimen (p < 0.015). Only the combination regimens
significantly suppressed phosphorylation of protein kinase B (Akt)
and nuclear factor-κB (NF-κB) p65 (p <
0.044). The combination of CUR and SAL reduces the concentration of
proinflammatory cytokines and diminishes activation of Akt and NF-κB
more effectively than CUR alone, providing a scientific basis for
examining whether this combination mitigates the risk of CRC in obese
individuals.
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Wu, Xian; C. Pfalzer, Anna; Koh, Gar Yee; Tang, Sanyuan; W. Crott, Jimmy; Thomas, Michael J.; et al. (2017). Curcumin and Salsalate Suppresses Colonic Inflammation
and Procarcinogenic Signaling in High-Fat-Fed, Azoxymethane-Treated
Mice. ACS Publications. Collection. https://doi.org/10.1021/acs.jafc.7b02648
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AUTHORS (8)
XW
Xian Wu
AC
Anna C. Pfalzer
GK
Gar Yee Koh
ST
Sanyuan Tang
JW
Jimmy W. Crott
MT
Michael J. Thomas
MM
Mohsen Meydani
JB
Joel B. Mason