Copper-Catalyzed Selective Arylation of Nitriles with
Cyclic Diaryl Iodonium Salts: Direct Access to Structurally Diversified
Diarylmethane Amides with Potential Neuroprotective and Anticancer
Activities
Posted on 2020-07-17 - 15:09
A novel, simple,
and high-yielding approach for the preparation
of diarylmethane amide derivatives has been developed by reacting
cyclic diaryl iodonium salts with nitriles using CuCl as a catalyst.
The procedure is efficient with high atom economy and a wide substrate
range. Importantly, selective arylation of nitriles was obtained without
affecting the phenyl amino/hydroxyl groups. Furthermore, two of the
diarylmethane amides (3k, 3s) displayed
excellent neuroprotective and anticancer activities.
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Peng, Xiaopeng; Sun, Zhiqiang; Kuang, Peihua; Li, Ling; Chen, Jingxuan; Chen, Jianjun (2020). Copper-Catalyzed Selective Arylation of Nitriles with
Cyclic Diaryl Iodonium Salts: Direct Access to Structurally Diversified
Diarylmethane Amides with Potential Neuroprotective and Anticancer
Activities. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.0c01829
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AUTHORS (6)
XP
Xiaopeng Peng
ZS
Zhiqiang Sun
PK
Peihua Kuang
LL
Ling Li
JC
Jingxuan Chen
JC
Jianjun Chen
KEYWORDS
atom economyCuClDirect Accessanticancer activitiesCopper-CatalyzedArylationImportantlyneuroprotectiveNitrileapproachdiarylmethane amide derivatives3 karylationphenylcatalystnitrilediarylmethane amidescyclic diaryl iodonium saltsCyclic Diaryl Iodonium SaltsStructurally Diversified Diarylmeth...Anticancer ActivitiespreparationPotential Neuroprotectivesubstrate rangeprocedure