Copper-Catalyzed Modular
Assembly of Polyheterocycles

Dömling, Alexander

Copper-Catalyzed Modular Assembly of Polyheterocycles

Posted on 2020-07-13 - 04:37

Easy operation, readily accessible starting materials, and short syntheses of the privileged scaffold indeno[1,2-c]isoquinolinone were achieved by an multicomponent reaction (MCR)-based protocol via an ammonia–Ugi-four component reaction (4CR)/copper-catalyzed annulation sequence. The optimization and scope and limitations of this short and general sequence are described. The methodology allows an efficient construction of a wide variety of indenoisoquinolinones in just two steps.

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Wang, Qian; Tuinhof, Jesse; Mgimpatsang, Kumchok C.; Kurpiewska, Katarzyna; Kalinowska-Tluscik, Justyna; Dömling, Alexander (2020). Copper-Catalyzed Modular Assembly of Polyheterocycles. ACS Publications. Collection. https://doi.org/10.1021/acs.joc.0c01238

https://doi.org/10.1021/acs.joc.0c01238

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