Convergent Synthesis of the Quinolone
Substructure of BILN 2061 via Carbonylative
Sonogashira Coupling/Cyclization

Farina, Vittorio

Convergent Synthesis of the Quinolone Substructure of BILN 2061 via Carbonylative Sonogashira Coupling/Cyclization

Posted on 2006-06-23 - 00:00

A convergent synthesis of quinolone 2 (key substructure of the protease inhibitor BILN 2061) was developed via palladium-catalyzed carbonylation of 2-iodo-5-methoxyaniline (4) with thiazolylacetylene 5.

CITE THIS COLLECTION

Haddad, Nizar; Tan, Jonathan; Farina, Vittorio (2016). Convergent Synthesis of the Quinolone Substructure of BILN 2061 via Carbonylative Sonogashira Coupling/Cyclization. ACS Publications. Collection. https://doi.org/10.1021/jo060556q

https://doi.org/10.1021/jo060556q

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