Collagen-Based Microcapsules As Therapeutic Materials
for Stem Cell Therapies in Infarcted Myocardium
Posted on 2020-06-22 - 20:30
As
cell therapies emerged, it was quickly realized that pro-regenerative
cells directly injected into injured tissue struggled within the inflammatory
microenvironment. By using microencapsulation, i.e., encapsulating
cells within polymeric biomaterials, they are henceforth protected
from the harmful extracellular cues, while still being able to receive
oxygen and nutrients and release secreted factors. Previous work showed
that stem cells encapsulated within a biologically inert material
(agarose) were able to significantly improve the function of the infarcted
mouse heart. With the aim of using more bioresponsive microcapsules,
we sought to develop an enzymatically degradable, type I collagen-based
microcapsule for the intramyocardial delivery of bone marrow-derived
mesenchymal stromal cells in a murine model of myocardial infarction.
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Jacques, Erik; Hosoyama, Katsuhiro; Biniam, Brook; Eren Cimenci, Cagla; Sedlakova, Veronika; Steeves, Alexander J.; et al. (2020). Collagen-Based Microcapsules As Therapeutic Materials
for Stem Cell Therapies in Infarcted Myocardium. ACS Publications. Collection. https://doi.org/10.1021/acsbiomaterials.0c00245