Clinical Significance
of Porphyromonas gingivalis Enriching Cancer Stem
Cells by Inhibiting Programmed Cell Death
Factor 4 in Esophageal Squamous Cell Carcinoma
Posted on 2023-09-19 - 04:29
Studies have confirmed that the colonization of Porphyromonas
gingivalis (Pg) could promote the malignant evolution of
esophageal squamous cell carcinoma (ESCC). Since pathogenic microorganisms
can promote malignant tumor proliferation by inhibiting programmed
cell death factor 4 (PDCD4) and the decrease of PDCD4 activity can
enhance the stemness of cancer cells, we here investigated the functional
mechanism by which Pg promoted ESCC chemoresistance and malignancy
through inhibiting PDCD4 and enriching cancer stem cells (CSCs). The
effects of Pg and PDCD4 on CSCs, chemoresistance and malignancy of
ESCC cells were evaluated by in vitro studies. The expression of Pg,
PDCD4, and ALDH1 in ESCC tissues were detected by IHC, and the correlations
between each index and postoperative survival of ESCC patients were
analyzed. The results showed that Pg could inhibit PDCD4 expression
and lead to CSCs enrichment in ESCC cells. After eliminating Pg, the
expression of PDCD4 was upregulated, the percentage of CSCs, chemoresistance
and malignancy were decreased. ESCC patients with Pg-positive, PDCD4-negative,
and ALDH1-positive have a significant shorter survival. This study
proved that eliminating Pg and blocking CSCs enrichment caused by
decreasing PDCD4 activity may provide a new strategy for ESCC treatment.
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Li, Ruonan; Liu, Yiwen; Zhou, Fuyou; Yang, Haijun; Li, Junkuo; Dai, Ningtao; et al. (2023). Clinical Significance
of Porphyromonas gingivalis Enriching Cancer Stem
Cells by Inhibiting Programmed Cell Death
Factor 4 in Esophageal Squamous Cell Carcinoma. ACS Publications. Collection. https://doi.org/10.1021/acsinfecdis.3c00182