Characterization of Retinol Stabilized in Phosphatidylcholine
Vesicles with and without Antioxidants
Posted on 2020-07-10 - 18:44
Retinol stability
has been reported to be improved by encapsulation
in liposomes, both with and without cholesterol. However, this improvement
is limited because of lipid peroxidation. In this study, we compare
the stability of retinol in phosphatidylcholine liposomes under ultraviolet
(UV) light or standard room air, with and without the addition of
antioxidants. Both butylated hydroxytoluene (BHT) and a proprietary
mix (StoppOx) improved the shelf stability from <10 to over 30
d. The addition of cholesterol had no effect. Fluorescence imaging
showed a heterogeneous distribution of retinol within the vesicles,
including within the aqueous layer. Fluorescence lifetimes were equally
heterogeneous. Under UV irradiation, StoppOx protected retinol for
significantly longer than BHT and via different mechanisms. This suggests
that natural antioxidants work well to improve the retinol stability,
but that further work to determine the optimal vesicle structure remains
to be performed.
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Chmykh, Yekaterina
G.; Nadeau, Jay L. (1753). Characterization of Retinol Stabilized in Phosphatidylcholine
Vesicles with and without Antioxidants. ACS Publications. Collection. https://doi.org/10.1021/acsomega.0c02102
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AUTHORS (2)
YC
Yekaterina
G. Chmykh
JN
Jay L. Nadeau