Carry-On Nitric-Oxide Luggage for Enhanced Chemotherapeutic
Efficacy
Posted on 2020-06-16 - 19:34
In this work, we
proposed a carry-on nitric-oxide (NO) luggage
strategy for enhanced chemotherapeutic efficacy. A stimuli-responsive
NO-releasing polypeptide was prepared as the building block to assemble
into a micelle as a chemodrug-carrier. The micelle was anchored with
cRGD peptide with the aim of targeting to tumors’ neoangiogenesis. In situ generation of NO at the tumor site can promote the
neovascularization to recruit more chemotherapeutics. Besides, the
introduced exogenous NO can directly induce apoptosis, synergistically
with the chemotherapeutics. A specific near-infrared-region (NIR)
NO-probe was also developed to be coloaded to the micelle to report
the in situ NO-release. In vitro and in vivo experiments were performed to demonstrate
the targeting capability, increased accumulation, real-time NO-release
reporting phenomenon, improved antitumor efficacy, and favorable biosafety.
Embedding NO into drug cargo as carry-on luggage for enhanced chemotherapeutic
efficacy, hopefully, can cast new lights and build a basic principle
in the future clinical translation of nanomedicines.
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Sun, Tao; Ding, Yunhui; Wang, Xiaofei; Zhang, Kai; Zhang, Guang-Ping; Liang, Donghui; et al. (2020). Carry-On Nitric-Oxide Luggage for Enhanced Chemotherapeutic
Efficacy. ACS Publications. Collection. https://doi.org/10.1021/acs.nanolett.0c01532
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AUTHORS (10)
TS
Tao Sun
YD
Yunhui Ding
XW
Xiaofei Wang
KZ
Kai Zhang
GZ
Guang-Ping Zhang
DL
Donghui Liang
KY
Kunjiao Yu
YC
Yongchao Chu
QC
Qinjun Chen
CJ
Chen Jiang