Cacalol Acetate, a Sesquiterpene from Psacalium
decompositum, Exerts an Anti-inflammatory Effect through
LPS/NF-KB Signaling in Raw 264.7 Macrophages
Posted on 2020-07-16 - 19:08
Inflammatory diseases remain critical
health problems worldwide.
The search for anti-inflammatory drugs is a primary activity in the
pharmaceutical industry. Cacalol is a sesquiterpene with anti-inflammatory
potential that is isolated from Psacalium decompositum, a medicinal plant with several scientific reports supporting its
anti-inflammatory activity. Cacalol acetate (CA) is the most stable
form. Nevertheless, the participation of CA in the main signaling
pathway associated with inflammation is unknown. Our aim was to study
the anti-inflammatory effect of CA and to determine its participation
in NF-κB signaling. In TPA-induced edema in mice, CA produced
70.3% inhibition. To elucidate the influence of CA on the NF-κB
pathway, RAW 264.7 macrophages were pretreated with CA and then stimulated
with LPS, evaluating NF-ΚB activation, IKK phosphorylation,
IΚB-α, p65, cytokine expression, and COX-2 release and
activity. CA inhibited NF-κB activation and its upstream signaling,
decreasing phosphorylation IKB-α and p65 levels. CA also reduced
expression and secretion of TNF-α, IL-1β, and IL-6. Additionally,
it decreased the activity and expression of COX-2 mRNA. These data
support that CA regulates the NF-κB signaling pathway, which
might explain, at least in part, its anti-inflammatory effect. CA
is a bioactive molecule useful for the development of anti-inflammatory
agents with innovative mechanisms of action.
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Mora-Ramiro, B.; Jiménez-Estrada, M.; Zentella-Dehesa, A.; Ventura-Gallegos, J. L.; Gomez-Quiroz, L. E.; Rosiles-Alanis, W.; et al. (2020). Cacalol Acetate, a Sesquiterpene from Psacalium
decompositum, Exerts an Anti-inflammatory Effect through
LPS/NF-KB Signaling in Raw 264.7 Macrophages. ACS Publications. Collection. https://doi.org/10.1021/acs.jnatprod.0c00300