Biomimetic Synthesis Enables the Structure Revision
of Littordials E and F and Drychampone B

George, Jonathan H.

Biomimetic Synthesis Enables the Structure Revision of Littordials E and F and Drychampone B

Posted on 2020-10-06 - 18:34

Structural reassignments for littordial E, littordial F, and drychampone B are proposed on the basis of consideration of their biosynthetic origin. The key step in the proposed biosynthesis of each of these meroterpenoids is an intermolecular hetero-Diels–Alder reaction between an o-quinone methide and caryophyllene or humulene. Biomimetic total synthesis of the natural products gave sufficient material to allow their structure revision by NMR studies.

CITE THIS COLLECTION

Vieira de Castro, Tomás; Yahiaoui, Oussama; Peralta, Ricardo A.; Fallon, Thomas; Lee, Victor; George, Jonathan H. (2020). Biomimetic Synthesis Enables the Structure Revision of Littordials E and F and Drychampone B. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.0c03156

https://doi.org/10.1021/acs.orglett.0c03156

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