Bioactivity-Guided Isolation of Potential Antidiabetic
and Antihyperlipidemic Compounds from Trigonella stellata
Posted on 2018-04-20 - 18:37
The in vitro antidiabetic and antihyperlipidemic
activities of
an alcoholic extract of Trigonella stellata were
evaluated in terms of the activation of PPARα and
PPARγ in human hepatoma (HepG2) cells. The extract
was investigated phytochemically, aiming at the isolation of the most
active compounds to be used as a platform for drug discovery. Three
new isoflavans, (3S,4R)-4,2′,4′-trihydroxy)-7-methoxyisoflavan
(1), (3R,4S)-4,2′,4′-trihydroxy-7-methoxy-4′-O-β-d-glucopyranosylisoflavan (2), and (2S,3R,4R)-4,2′,4′-trihydroxy-2,7-dimethoxyisoflavan (3), were isolated and characterized along with the five known
compounds p-hydroxybenzoic acid (4),
7,4′-dihydroxyflavone (5), dihydromelilotoside
(6), quercetin-3,7-O-α-l-dirhamnoside (7), and soyasaponin I (8). The structures of 1–3 were elucidated
using various spectroscopic techniques including HRESIMS and 1D and
2D NMR. The absolute stereochemistry of the new isoflavans (1–3) was determined using both experimental
and calculated electronic circular dichroism as well as DP4 calculations.
The isolated compounds were tested for their PPARα and PPARγ activation effects in HepG2 cells.
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Shams Eldin, Safa M.; Radwan, Mohamed
M.; Wanas, Amira S.; Habib, Abdel-Azim M.; Kassem, Fahima F.; M. Hammoda, Hala; et al. (2018). Bioactivity-Guided Isolation of Potential Antidiabetic
and Antihyperlipidemic Compounds from Trigonella stellata. ACS Publications. Collection. https://doi.org/10.1021/acs.jnatprod.7b00707
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AUTHORS (10)
SS
Safa M. Shams Eldin
MR
Mohamed
M. Radwan
AW
Amira S. Wanas
AH
Abdel-Azim M. Habib
FK
Fahima F. Kassem
HM
Hala M. Hammoda
SK
Shabana
I. Khan
MK
Michael L. Klein
KE
Khaled M. Elokely
ME
Mahmoud A. ElSohly