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Asymmetric Transfer Hydrogenation of Heterobicyclic Alkenes with Water as Hydrogen Source

Posted on 2019-02-12 - 14:50
The asymmetric transfer hydrogenation of heterobicyclic alkenes was accomplished by using water as the sole hydrogen source. The transformation was co-catalyzed by Pd­(OAc)2/Zn­(OTf)2 dual catalyst with metallic zinc as reducing agent. Various azabenzonorbornadienes and oxabenzonorbornadienes were transformed to the corresponding chiral 1,2-dihydronaphthalenes by the asymmetric reductive ring-opening reactions with good to excellent enantioselectivities.

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