Assessing
the Mixture Effects in In Vitro Bioassays of Chemicals
Occurring in Small Agricultural Streams during
Rain Events
Posted on 2020-06-22 - 10:03
Rain events may impact the chemical
pollution burden in rivers.
Forty-four small streams in Germany were profiled during several rain
events for the presence of 395 chemicals and five types of mixture
effects in in vitro bioassays (cytotoxicity; activation
of the estrogen, aryl hydrocarbon, and peroxisome proliferator-activated
receptors; and oxidative stress response). While these streams were
selected to cover a wide range of agricultural impacts, in addition
to the expected pesticides, wastewater-derived chemicals and chemicals
typical for street runoff were detected. The unexpectedly high estrogenic
effects in many samples indicated the impact by wastewater or overflow
of combined sewer systems. The 128 water samples exhibited a high
diversity of chemical and effect patterns, even for different rain
events at the same site. The detected 290 chemicals explained only
a small fraction (<8%) of the measured effects. The experimental
effects of the designed mixtures of detected chemicals that were expected
to dominate the mixture effects of detected chemicals were consistent
with predictions for concentration addition within a factor of two
for 94% of the mixtures. Overall, the burden of chemicals and effects
was much higher than that previously detected in surface water during
dry weather, with the effects often exceeding proposed effect-based
trigger values.
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Neale, Peta A.; Braun, Georg; Brack, Werner; Carmona, Eric; Gunold, Roman; König, Maria; et al. (2020). Assessing
the Mixture Effects in In Vitro Bioassays of Chemicals
Occurring in Small Agricultural Streams during
Rain Events. ACS Publications. Collection. https://doi.org/10.1021/acs.est.0c02235