Aspartame and Its
Microhydrated Aggregates Revealed
by Laser Spectroscopy: Water–Sweetener Interactions in the
Gas Phase
Posted on 2024-08-02 - 07:44
The popular sweetener, aspartame, is an agonist of the
tongue’s
sweet taste receptor. How water molecules affect its conformation
or which aspartame atoms are more prone to interact with solvent are
helpful questions to understand its activity in different environments.
Here, the combination of IR–UV spectroscopic techniques with
computational simulations has been successfully applied to characterize
aspartame·water0–2 clusters, showing that the
addition of water molecules simplifies the conformational panorama
of aspartame, favoring the formation of folded structures by interaction
with the polar part of the molecule.
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Pinillos, Paul; Camiruaga, Ander; Torres-Hernández, Fernando; Çarçabal, Pierre; Usabiaga, Imanol; Fernández, José A.; et al. (2024). Aspartame and Its
Microhydrated Aggregates Revealed
by Laser Spectroscopy: Water–Sweetener Interactions in the
Gas Phase. ACS Publications. Collection. https://doi.org/10.1021/acs.jpca.4c04315