Antiproliferative Flavanoid Dimers Isolated from Brazilian
Red Propolis
Posted on 2020-06-11 - 13:03
Herein reported are results of the
chemical and biological investigation
of red propolis collected at the Brazilian Northeast coastline. New
propolones A–D (1–4), with
a 3-{3-[(2-phenylbenzofuran-3-yl)methyl]phenyl}chromane
skeleton; propolonones A–C (5–7), with a 3-[3-(3-benzylbenzofuran-2-yl)phenyl]chromane
skeleton; and propolol A (8), with a 6-(3-benzylbenzofuran-2-yl)-3-phenylchromane
skeleton, were isolated as constituents of Brazilian red propolis
by cytotoxicity-guided assays and structurally identified by analysis
of their spectroscopic data. Propolone B (2) and propolonone
A (5) display significant cytotoxic activities against
an ovarian cancer cell line expressing a multiple drug resistance
phenotype when compared with doxorubicin.
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Banzato, Thais
P.; Gubiani, Juliana R.; Bernardi, Darlon I.; Nogueira, Cláudio
R.; Monteiro, Afif F.; Juliano, Fernanda F.; et al. (2020). Antiproliferative Flavanoid Dimers Isolated from Brazilian
Red Propolis. ACS Publications. Collection. https://doi.org/10.1021/acs.jnatprod.9b01136
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AUTHORS (15)
TB
Thais
P. Banzato
JG
Juliana R. Gubiani
DB
Darlon I. Bernardi
CN
Cláudio
R. Nogueira
AM
Afif F. Monteiro
FJ
Fernanda F. Juliano
Sd
Severino M. de Alencar
RP
Ronaldo A. Pilli
CL
Carolina A. de Lima
GL
Giovanna B. Longato
AF
Antonio G. Ferreira
MF
Mary Ann Foglio
JC
João E.
de Carvalho
DV
Débora B. Vendramini-Costa
RB
Roberto G. S. Berlinck