Antifungal and Cytotoxic β‑Resorcylic Acid Lactones from a Paecilomyces Species
Posted on 2017-07-27 - 18:19
Eight new β-resorcylic acid
lactones (RALs), including the hypothemycin-type compounds paecilomycins
N–P (1–3) and the radicicol-type
metabolites dechloropochonin I (4), monocillins VI (5) and VII (6), 4′-hydroxymonocillin IV
(7), and 4′-methoxymonocillin IV (8), along with nine known RALs (9–17), were isolated from the cultures of Paecilomyces sp. SC0924. Compounds 1 and 2 feature
a novel 6/11/5 ring system, and 3 is the first 5′-keto
RAL. The structures of 1–8 were elucidated
on the basis of extensive spectroscopic analysis, X-ray diffraction
analysis, and theoretical calculations of ECD spectra. Compounds 3, 5, and 6 exhibit cytotoxicity
against MCF-7, A549, and HeLa cells, and compounds 5 and 7 display antifungal activity against Peronophythora
litchii.
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Xu, Liangxiong; Wu, Ping; Xue, Jinghua; Molnar, Istvan; Wei, Xiaoyi (2017). Antifungal and Cytotoxic β‑Resorcylic Acid Lactones from a Paecilomyces Species. ACS Publications. Collection. https://doi.org/10.1021/acs.jnatprod.7b00066
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AUTHORS (5)
LX
Liangxiong Xu
PW
Ping Wu
JX
Jinghua Xue
IM
Istvan Molnar
XW
Xiaoyi Wei
KEYWORDS
7 display antifungal activityRALVIIPeronophythora litchiiCompounds 3X-ray diffraction analysisPaecilomyces spSC 0924. Compounds 1HeLa cellsβ- resorcylic acid lactonesradicicol-type metabolites dechloropochonincompounds 5Paecilomyces Species2 feature6 exhibit cytotoxicityECD spectraVIIVspectroscopic analysisMCF