An
Ultrasmall RuO2 Nanozyme Exhibiting
Multienzyme-like Activity for the Prevention of Acute Kidney Injury
Posted on 2020-07-06 - 16:08
Oxidative
stress induced by reactive oxygen species (ROS) is one
of the major pathological mechanisms of acute kidney injury (AKI).
Inorganic nanomaterial-mediated antioxidant therapy is considered
a promising method for the prevention of AKI; however, currently available
antioxidants for AKI exhibit limited clinical efficacy due to the
glomerular filtration threshold (∼6 nm). To address this issue,
we developed ultrasmall RuO2 nanoparticles (RuO2NPs) (average size ≈ 2 nm). The NPs show excellent antioxidant
activity and low biological toxicity. In addition, they can pass through
the glomerulus to be excreted. These properties in combination make
the ultrasmall RuO2NPs promising as a nanozyme for the
prevention of AKI. The NP catalytic properties mimic the activity
of catalase, peroxidase, superoxide dismutase, and glutathione peroxidase.
The nanozyme can be efficiently and rapidly absorbed by human embryonic
kidney cells while significantly reducing ROS-induced apoptosis by
eliminating excess ROS. After intravenous injection, the ultrasmall
RuO2NPs significantly inhibit the development of AKI in
mice. In vivo toxicity experiments demonstrate the biosafety of the
NPs after long-term preventing. The multienzyme-like activity and
biocompatibility of the ultrasmall RuO2NPs makes them of
great interest for applications in the fields of biomedicine and biocatalysis.
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Liu, Zhou; Xie, Lina; Qiu, Kangqiang; Liao, Xinxing; Rees, Thomas W.; Zhao, Zizhuo; et al. (2020). An
Ultrasmall RuO2 Nanozyme Exhibiting
Multienzyme-like Activity for the Prevention of Acute Kidney Injury. ACS Publications. Collection. https://doi.org/10.1021/acsami.0c07886