AgSbF₆‑Mediated Selective Thiolation and Selenylation at C‑4 Position of Isoquinolin-1(2H)‑ones

A new and facile AgSbF₆-mediated protocol for the construction of C-4 thiolated or selenylated isoquinolin-1­(2H)-ones via a radical pathway was established. This reaction proceeded efficiently with excellent regioselectivity, a broad substrate scope, and good functional group tolerance. A radical reaction mechanism involving thiyl radicals as key intermediates is proposed for the present transformation.