Ag-Catalyzed Oxidative ipso-Cyclization
via Decarboxylative Acylation/Alkylation: Access to 3‑Acyl/Alkyl-spiro[4.5]trienones

Prajapti, Santosh Kumar

Ag-Catalyzed Oxidative ipso-Cyclization via Decarboxylative Acylation/Alkylation: Access to 3‑Acyl/Alkyl-spiro[4.5]trienones

Posted on 2020-06-30 - 21:04

A strategy to functionalized spiro[4.5]trienones, by domino silver-catalyzed decarboxylative acylation or alkylation/ ipso-cyclization of N-arylpropiolamides with α-keto acids/alkyl carboxylic acids, is presented. This transformation offers a wide range of substituted 3-acyl/alkyl-spiro[4.5]trienones in high yields with a broad substrate scope. The approach was further extended to access fused tricyclic frameworks, 6,7-dihydro-3H-pyrrolo[2,1-j]quinoline-3,9(5H)-diones.

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Reddy, Chada Raji; Kolgave, Dattahari H.; Subbarao, Muppidi; Aila, Mounika; Prajapti, Santosh Kumar (2020). Ag-Catalyzed Oxidative ipso-Cyclization via Decarboxylative Acylation/Alkylation: Access to 3‑Acyl/Alkyl-spiro[4.5]trienones. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.0c01588

https://doi.org/10.1021/acs.orglett.0c01588

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