Additive- and Ligand-Free Cross-Coupling Reactions between Alkenes and Alkynes by Iridium Catalysis

Published on 2019-06-12T14:43:56Z (GMT) by
Although a range of transition-metal-catalyzed cross-coupling reactions of alkenes and alkynes have been developed to produce valuable conjugated dienes, extension of these reactions to iridium catalysis has yet to be demonstrated. The first iridium-catalyzed alkene–alkyne cross-coupling reactions have been realized under ligand- and additive-free conditions. A wide range of acrylamides and alkynes could be used as coupling partners, providing branched (<i>Z</i>,<i>Z</i>)-butadiene skeletons with excellent site- and stereoselectivities. The utility of this approach is also demonstrated by preparative-scale and C–H functionalization of perillic and artemisic amides.

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Sun, Yaling; Meng, Keke; Zhang, Jian; Jin, Mengxin; Huang, Nini; Zhong, Guofu (2019): Additive- and Ligand-Free Cross-Coupling Reactions

between Alkenes and Alkynes by Iridium Catalysis. ACS Publications. Collection.