Acid-Responsive and Biologically Degradable Polyphosphazene
Nanodrugs for Efficient Drug Delivery
Posted on 2020-06-15 - 19:08
To
enhance the therapeutic effects and reduce the damage to normal
tissues in cancer chemotherapy, it is indispensable to develop drug
delivery carriers with controllable release and good biocompatibility.
In this work, acid-responsive and degradable polyphosphazene (PPZ)
nanoparticles were synthesized by the reaction of hexachlorotripolyphosphonitrile
(HCCP) with 4-hydroxy-benzoic acid (4-hydroxy-benzylidene)-hydrazide
(HBHBH) and anticancer drug doxorubicin (DOX). The controlled release
of DOX could be realized based on the acid responsiveness of acylhydrazone
in HBHBH. Experimental results showed that polyphosphazene nanoparticles
remained stable in the body’s normal fluids (pH ∼ 7.4),
while they were degraded and controllable release of DOX in an acidic
environment such as tumors (pH ∼ 6.8) and lysosome and endosome
(∼5.0) in cancer cells In particular, the doxorubicin (DOX)-loading
ratio was fair high and could be tuned from 10.6 to 52.6% by changing
the dosing ratio of DOX to HBHBH. Meanwhile, the polyphosphazene nanodrugs
showed excellent toxicity to tumor cells and reduced the side effect
to normal cells both in vitro and in vivo due to their enhanced permeability
and retention (EPR) effect and pH-sensitive degradation properties.
Therefore, the constructed pH-sensitive drug delivery system has great
potential for cancer chemotherapy.
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Zhou, Na; Zhi, Zhe; Liu, Daomeng; Wang, Daquan; Shao, Yongping; Yan, Kai; et al. (2020). Acid-Responsive and Biologically Degradable Polyphosphazene
Nanodrugs for Efficient Drug Delivery. ACS Publications. Collection. https://doi.org/10.1021/acsbiomaterials.0c00378
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AUTHORS (8)
NZ
Na Zhou
ZZ
Zhe Zhi
DL
Daomeng Liu
DW
Daquan Wang
YS
Yongping Shao
KY
Kai Yan
LM
Lingjie Meng
DY
Demei Yu