Absorption of Anthocyanin Rutinosides after Consumption
of a Blackcurrant (Ribes nigrum L.) Extract
Version 2 2019-06-26, 23:43Version 2 2019-06-26, 23:43
Version 1 2019-06-07, 20:13Version 1 2019-06-07, 20:13
Posted on 2019-06-26 - 23:43
The
dominant anthocyanins in blackcurrant are delphinidin-3-O-rutinoside
and cyanidin-3-O-rutinoside. Data on their absorption and distribution
in the human body are limited. Therefore, we performed a human pilot
study on five healthy male volunteers consuming a blackcurrant (Ribes nigrum L.) extract. The rutinosides and their degradation
products gallic acid and protocatechuic acid were determined in plasma
and urine. The rutinosides’ concentrations peaked in both plasma
and urine samples within 2 h of extract ingestion. The recoveries
of delphinidin-3-O-rutinoside and cyanidin-3-O-rutinoside from urine
samples were 0.040 ± 0.011% and 0.048 ± 0.016%, respectively,
over a 48 h period. Protocatechuic acid concentration increased significantly
after ingestion of the blackcurrant extract. Our results show that
after ingestion of a blackcurrant extract containing delphinidin-3-O-rutinoside
and cyanidin-3-O-rutinoside, significant quantities of biologically
active compounds circulated in the plasma and were excreted via urine.
Furthermore, these results contribute to the understanding of anthocyanin
metabolism in humans.
CITE THIS COLLECTION
DataCite
DataCiteDataCite
3 Biotech3 Biotech
3D Printing in Medicine3D Printing in Medicine
3D Research3D Research
3D-Printed Materials and Systems3D-Printed Materials and Systems
4OR4OR
AAPG BulletinAAPG Bulletin
AAPS OpenAAPS Open
AAPS PharmSciTechAAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität HamburgAbhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)ABI Technik (German)
Academic MedicineAcademic Medicine
Academic PediatricsAcademic Pediatrics
Academic PsychiatryAcademic Psychiatry
Academic QuestionsAcademic Questions
Academy of Management DiscoveriesAcademy of Management Discoveries
Academy of Management JournalAcademy of Management Journal
Academy of Management Learning and EducationAcademy of Management Learning and Education
Academy of Management PerspectivesAcademy of Management Perspectives
Academy of Management ProceedingsAcademy of Management Proceedings
Academy of Management ReviewAcademy of Management Review
Röhrig, Teresa; Kirsch, Verena; Schipp, Dorothea; Galan, Jens; Richling, Elke (2019). Absorption of Anthocyanin Rutinosides after Consumption
of a Blackcurrant (Ribes nigrum L.) Extract. ACS Publications. Collection. https://doi.org/10.1021/acs.jafc.9b01567