A
Physically Triggered Cell Death via Transbarrier
Cold Atmospheric Plasma Cancer Treatment
Posted on 2020-07-23 - 21:30
Cold
atmospheric plasma (CAP) is a near room-temperature ionized
gas composed of highly reactive species. CAP also generates thermal
radiation, ultraviolet radiation, and electromagnetic (EM) waves.
So far, nearly all biological effects of CAP have relied on the chemical
factors in CAP. Here, we first show that the EM emission from CAP
can lead to the death of melanoma cells via a transbarrier contactless
method. Compared with reactive species, the effect of the physical
factors causes much stronger growth inhibition on a reactive species-resistant
melanoma cell line B16F10. Such a physically triggered growth inhibition
is due to a new cell death type, characterized by the rapid leakage
of bulk solutions from the cells, resulting in cytoplasm shrinkage
and bubbling on the cell membrane. The physically based CAP-triggered
cell death can occur even there is a macroscale gap between the bulk
CAP and cells, which includes an air gap (∼8 mm) and a dielectric
material of the dish or plate (∼1 mm). Either a too large or
a too small gap will inhibit such cell death. The physically triggered
cellular pressure may cause the bubbling on cells, which can be inhibited
in a hypotonic environment via the extracellular osmotic pressure.
This study builds a foundation to use CAP as a physically based noninvasive
cancer treatment.
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Yan, Dayun; Wang, Qihui; Adhikari, Manish; Malyavko, Alisa; Lin, Li; Zolotukhin, Denis B.; et al. (2020). A
Physically Triggered Cell Death via Transbarrier
Cold Atmospheric Plasma Cancer Treatment. ACS Publications. Collection. https://doi.org/10.1021/acsami.0c06500
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AUTHORS (10)
DY
Dayun Yan
QW
Qihui Wang
MA
Manish Adhikari
AM
Alisa Malyavko
LL
Li Lin
DZ
Denis B. Zolotukhin
XY
Xiaoliang Yao
MK
Megan Kirschner
JS
Jonathan H. Sherman
MK
Michael Keidar