A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights
Posted on 2015-12-16 - 15:55
Tanshinones are abietane-type norditerpenoid quinone natural products that are the bioactive components of the Chinese medicinal herb Salvia miltiorrhiza Bunge. The initial results from a functional genomics-based investigation of tanshinone biosynthesis, specifically the functional identification of the relevant diterpene synthases from S. miltiorrhiza, are reported. The cyclohexa-1,4-diene arrangement of the distal ring poises the resulting miltiradiene for the ensuing aromatization and hydroxylation to ferruginol suggested for tanshinone biosynthesis.
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Gao, Wei; Hillwig, Matthew L.; Huang, Luqi; Cui, Guanghong; Wang, Xueyong; Kong, Jianqiang; et al. (2015). A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights. ACS Publications. Collection. https://doi.org/10.1021/ol902051v
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AUTHORS (8)
- WGWei GaoMHMatthew L. HillwigLHLuqi HuangGCGuanghong CuiXWXueyong WangJKJianqiang KongBYBin YangRPReuben J. Peters
KEYWORDS
herb Salvia miltiorrhiza Bungemiltiradienetanshinone biosynthesisarrangementTanshinone Biosynthesis Provides Stereochemical Insights TanshinonesinvestigationidentificationferruginolcomponentpoisehydroxylationditerpenenorditerpenoidquinonesynthaseFunctional Genomics Approachbioactivearomatizationcyclohexa