7,11-epi-Thyrsiferol:  Completion of Its Synthesis, Evaluation of Its
Antimitotic Properties, and the Further Development of an
SAR Model

Little, R. Daniel

7,11-epi-Thyrsiferol: Completion of Its Synthesis, Evaluation of Its Antimitotic Properties, and the Further Development of an SAR Model

Posted on 2006-08-04 - 00:00

We (a) describe the completion of a total synthesis of 7,11-epi-thyrsiferol (4), (b) compare the antimitotic activities of thyrsiferol (2), Δ^15,28-dehydrothyrsiferol (3), and 7,11-epi-thyrsiferol (4), (c) evaluate the synergistic behavior of the title compound and colchicine to inhibit cell proliferation, and (d) describe the results of conformational searches that provide additional insight concerning the SAR profile of the thyrsiferol family of natural products.

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Nishiguchi, Gisele A.; Graham, John; Bouraoui, A.; Jacobs, R. S.; Little, R. Daniel (2016). 7,11-epi-Thyrsiferol: Completion of Its Synthesis, Evaluation of Its Antimitotic Properties, and the Further Development of an SAR Model. ACS Publications. Collection. https://doi.org/10.1021/jo060519z

https://doi.org/10.1021/jo060519z

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