mt9b00835_si_001.pdf (412.13 kB)
pH and Thermal Dual-Responsive Graphene Oxide Nanocomplexes for Targeted Drug Delivery and Photothermal-Chemo/Photodynamic Synergetic Therapy
journal contribution
posted on 2019-11-20, 04:13 authored by Junlong Liang, Biling Chen, Jinhua Hu, Qianwei Huang, Dianbo Zhang, Junmin Wan, Zhiwen Hu, Bing WangThe development of versatile nanoplatforms with efficient
tumor-targeting
properties and synergistic therapeutic strategies to realize effective
antitumor efficiency are highly anticipated in the field of cancer
therapy. Herein, we innovatively synthesized targeted nanocomplexes
(NCGO-FA) with nanoscale structures by a modified Hummers’
method and then used these nanocomplexes to separately load the doxorubicin
(DOX) and methylene blue (MB) via π–π stacking,
electrostatic attractions, and/or hydrophobic interactions, forming
NCGO@DOX-FA and NCGO@MB-FA nanoplatforms. The results demonstrated
that the NCGO-FA nanocomplexes have an ultrahigh surface area, a high-load
content of drugs, targeting specificity, and a good photothermal conversion
efficiency and photostability. Meanwhile, after loading the nanoplatforms
with DOX or MB, NCGO-FA delivered drugs into cancer cells by folic
acid (FA) receptors and triggered the drug release by heat and in
acidic tumor environments. More importantly, compared with individually
applied photothermal therapy, photodynamic therapy, or chemotherapy,
the photothermal-chemo or photothermal-photodynamic synergistic therapy
with the NCGO@DOX-FA or NCGO@MB-FA nanoplatform exhibits a remarkable
synergistic effect, resulting in a distinguished antitumor efficiency.
Consequently, this work proposes a facile and versatile method to
construct a dual-responsive versatile nanoplatform that combines photothermal-chemo
and photodynamic therapies, and these nanoplatforms have excellent
application prospects for tumor therapy.