pH-Switchable Strand Orientation in Peptide Assemblies

2005-02-03T00:00:00Z (GMT) by Nathan A. Schnarr Alan J. Kennan
The design of antiparallel coiled-coil heterotrimers with singly mismatched electrostatic interfaces is reported. The new complexes exhibit expected properties for well-formed coiled-coils and have stabilities comparable to those of parallel analogues. The mismatched interface facilitates switching from a parallel to antiparallel complex by pH-triggered strand exchange.