ol047720l_si_001.pdf (101.22 kB)
pH-Switchable Strand Orientation in Peptide Assemblies
journal contribution
posted on 2005-02-03, 00:00 authored by Nathan A. Schnarr, Alan J. KennanThe design of antiparallel coiled-coil heterotrimers with singly mismatched electrostatic interfaces is reported. The new complexes exhibit
expected properties for well-formed coiled-coils and have stabilities comparable to those of parallel analogues. The mismatched interface
facilitates switching from a parallel to antiparallel complex by pH-triggered strand exchange.