am6b04933_si_001.pdf (717.35 kB)
pH-Sensitive ZnO Quantum Dots–Doxorubicin Nanoparticles for Lung Cancer Targeted Drug Delivery
journal contribution
posted on 2016-07-27, 00:00 authored by Xiaoli Cai, Yanan Luo, Weiying Zhang, Dan Du, Yuehe LinIn this paper, we
reported a ZnO quantum dots-based pH-responsive drug delivery platform
for intracellular controlled release of drugs. Acid-decomposable,
luminescent aminated ZnO quantum dots (QDs) were synthesized as nanocarriers
with ultrasmall size (∼3 nm). The dicarboxyl-terminated poly(ethylene
glycol) (PEG) had been introduced to NH2–ZnO QDs,
which rendered it stable under physiological fluid. Moreover, a targeting
ligand, hyaluronic acid (HA), was conjugated to ZnO QDs for specifically
binding to the overexpressed glycoprotein CD44 by cancer cells. Doxorubicin
(DOX) molecules were successfully loaded to PEG functionalized ZnO
QDs via formation of metal–DOX complex and covalent interactions.
The pH-sensitive ZnO QDs dissolved to Zn2+ in acidic endosome/lysosome
after uptake by cancer cells, which triggered dissociation of the
metal–drug complex and a controlled DOX release. As result,
a synergistic therapy was achieved due to incorporation of the antitumor
effect of Zn2+ and DOX.