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Download fileSurface-Complexed Zinc Ferrite Magnetofluorescent Nanoparticles for Killing Cancer Cells and Single-Particle-Level Cellular Imaging
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posted on 04.06.2018, 00:00 authored by Uday Narayan Pan, Pallab Sanpui, Anumita Paul, Arun ChattopadhyayThe
fabrication of novel magnetofluorescent nanoparticles (NPs)
by complexation of zinc ions present on the surface of a zinc ferrite
nanoparticle (ZnFe2O4 NP) with 8-hydroxy-2-quinolinecarboxaldehyde
(HQCald) is reported. The as-prepared HQCald-complexed ZnFe2O4 NPs showed good quantum yield (3.62%), high photostability,
considerable excited-state lifetime (5.31 ns), and high saturation
magnetization (12.7 emu/g). These magnetofluorescent NPs demonstrated
bioimaging capability at both the ensemble- and single-particle levels
and in vitro magnetic targeting. Moreover, the pronounced antiproliferative
efficacy of these NPs against cancer cells, with appropriate targeting
strategies, can lead to potential cancer theranostics.
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antiproliferative efficacycancer theranosticsZnFe 2 O 4 NPnovel magnetofluorescent nanoparticlesSurface-Complexed Zinc Ferrite Magnetofluorescent Nanoparticles8- hydroxy -2-quinolinecarboxaldehydebioimaging capabilityas-prepared HQCald-complexed ZnFe 2 O 4 NPssingle-particle levelscancer cellsKilling Cancer Cellszinc ferrite nanoparticlezinc ionsmagnetofluorescent NPsSingle-Particle-Level Cellular Imaging