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Shape-Recoverable Macroporous Nanocomposite Hydrogels Created via Ice Templating Polymerization for Noncompressible Wound Hemorrhage
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posted on 2022-04-15, 12:09 authored by Lijing Teng, Kaide Xia, Tianbao Qian, Zuquan Hu, Liang Hong, Ying Liao, Guorui Peng, Zhongrun Yuan, Yunhua Chen, Zhu ZengUncontrolled
hemorrhage resulting from severe trauma or surgical
operations remains a challenge. It is highly important to develop
functional materials to treat noncompressible wound bleeding. In this
work, a shape-recoverable macroporous nanocomposite hydrogel was facilely
created through ice templating polymerization. The covalently cross-linked
gelatin networks provide a robust framework, while the Laponite nanoclay
disperses into the three-dimensional matrix, enabling mechanical reinforcement
and hemostatic functions. The resultant macroporous nanocomposite
hydrogel possesses an inherent interconnected macroporous structure
and rapid deformation recovery. In vitro assessments indicate that
the hydrogel displays good cytocompatibility and a low hemolysis ratio.
The hydrogel shows a higher coagulation potential and more erythrocyte
adhesion compared to the commercial gauze and gelatin sponge. The
noncompressible liver hemorrhage models also confirm its promising
hemostasis performance. This strategy of combining a nano-enabled
solution with ice templating polymerization displays great potential
to develop appealing absorbable macroporous biomaterials for rapid
hemostasis.
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vitro assessments indicatesurgical operations remainslow hemolysis ratiolaponite nanoclay dispersesice templating polymerizationhigher coagulation potentialerythrocyte adhesion comparedenabling mechanical reinforcementdevelop functional materialsrapid deformation recoverypromising hemostasis performancerapid hemostasissevere traumarobust frameworkhydrogel showshighly importanthemostatic functionsgelatin spongefacilely createdenabled solutiondimensional matrixcovalently crosscommercial gauze