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Practical Role of Racemization Rates in Deracemization Kinetics and Process Productivities
mediaposted on 2018-10-09, 00:00 authored by Ryusei Oketani, Marine Hoquante, Clément Brandel, Pascal Cardinael, Gérard Coquerel
Herein, we report the chiral symmetry breaking of 2-methoxy-1-naphthamide atropisomers through temperature cycling without the use of any racemization reagent. The racemization rate (k1) controls the deracemization process when the cooling of the slurry is slow enough to keep the system close to equilibrium. The productivity appears proportional to the racemization rate (k1) multiplied by the solubility.