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Plasmonically Coupled Nanoreactors for NIR-Light-Mediated Remote Stimulation of Catalysis in Living Cells
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posted on 2018-11-29, 00:00 authored by Amit Kumar, Sumit Kumar, Nitee Kumari, Seon Hee Lee, Jay Han, Issac J. Michael, Yoon-Kyoung Cho, In Su LeeArtificial
nanoreactors that can facilitate catalysis in living
systems on-demand with the aid of a remotely operable and biocompatible
energy source are needed to leverage the chemical diversity and expediency
of advanced chemical synthesis in biology and medicine. Here, we designed
and synthesized plasmonically integrated nanoreactors (PINERs) with
highly tunable structure and NIR-light-induced synergistic function
for efficiently promoting unnatural catalytic reactions inside living
cells. We devised a synthetic approach toward PINERs by investigating
the crucial role of metal-tannin coordination polymer nanofilmthe
pH-induced decomplexation-mediated phase-transition processfor
growing arrays of Au-nanospheroid-units, constructing a plasmonic
corona around the proximal and reactant-accessible silica-compartmentalized
catalytic nanospace. Owing to the extensive plasmonic coupling effect,
PINERs show strong and tunable optical absorption in the visible to
NIR range, ultrabright plasmonic light scattering, controllable thermoplasmonic
effect, and remarkable catalysis; and, upon internalization by living
cells, PINERs are highly biocompatible and demonstrate dark-field
microscpy-based bioimaging features. Empowered with the synergy between
plasmonic and catalytic effects and reactant/product transport, facilitated
by the NIR-irradiation, PINERs can perform intracellular catalytic
reactions with dramatically accelerated rates and efficiently synthesize
chemically activated fluorescence-probes inside living cells.
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Keywords
PINERs showchemical synthesisNIR-Light-Mediated Remote Stimulationdark-field microscpy-based bioimaging featuresbiocompatible energy sourceultrabright plasmonic lightchemical diversitythermoplasmonic effectreactant-accessible silica-compartmentalizedLiving Cellstunable structuresystems on-demandcatalysinanoreactorplasmonic coronaNIR range