ac049863r_si_002.avi (3.78 MB)
Pinched Flow Fractionation: Continuous Size Separation of Particles Utilizing a Laminar Flow Profile in a Pinched Microchannel
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posted on 2004-09-15, 00:00 authored by Masumi Yamada, Megumi Nakashima, Minoru SekiA concept of “pinched flow fractionation” for the continuous size separation and analysis of particles in microfabricated devices has been proposed and demonstrated. In
this method, particles suspended in liquid were continuously introduced into a microchannel having a pinched
segment and were aligned to one sidewall in the pinched
segment by another liquid flow without particles. The
particles were then separated perpendicularly to the flow
direction according to their sizes by the spreading flow
profile inside the microchannel. Polymer microbeads
were successfully separated, and the effects of the flow
rate and channel shapes on the separation performance
were examined. Also, separated particles were collected
independently by making branches at the end of the
pinched segment. Since this method utilizes only the
laminar flow profile inside a microchannel, complicated
outer field control could be eliminated, which is usually
required for other kinds of particle separation methods
such as field flow fractionation. Also, this method can be
applied both for particle size analysis and for preparation
of monodispersed particles, since separation can be
rapidly and continuously performed.
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laminar flow profilechannel shapesflow directionsize separationflow ratePinched Microchannelparticle separation methodsflow profilemicrofabricated devicesfield flow fractionationfield controlLaminar Flow Profileparticle size analysisParticles UtilizingPolymer microbeadsSize Separationseparation performancemonodispersed particles
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