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One-pot Synthesis of Metal–Organic Frameworks with Encapsulated Target Molecules and Their Applications for Controlled Drug Delivery
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posted on 2016-01-27, 00:00 authored by Haoquan Zheng, Yuning Zhang, Leifeng Liu, Wei Wan, Peng Guo, Andreas M. Nyström, Xiaodong ZouMany medical and chemical applications
require target molecules
to be delivered in a controlled manner at precise locations. Metal–organic
frameworks (MOFs) have high porosity, large surface area, and tunable
functionality and are promising carriers for such purposes. Current
approaches for incorporating target molecules are based on multistep
postfunctionalization. Here, we report a novel approach that combines
MOF synthesis and molecule encapsulation in a one-pot process. We
demonstrate that large drug and dye molecules can be encapsulated
in zeolitic imidazolate framework (ZIF) crystals. The molecules are
homogeneously distributed within the crystals, and their loadings
can be tuned. We show that ZIF-8 crystals loaded with the anticancer
drug doxorubicin (DOX) are efficient drug delivery vehicles in cancer
therapy using pH-responsive release. Their efficacy on breast cancer
cell lines is higher than that of free DOX. Our one-pot process opens
new possibilities to construct multifunctional delivery systems for
a wide range of applications.