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Download fileHierarchical Shish–Kebab Structures Functionalizing Nanofibers for Controlled Drug Release and Improved Antithrombogenicity
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posted on 2022-03-02, 20:13 authored by Meng Guo, Xiaofeng Wang, Yajing Liu, Haichang Yu, Jiahui Dong, Zhixiang Cui, Zhiyuan Bai, Kecheng Li, Qian LiThe functionalization of the fibrous
scaffolds including drug loading
and release is of significance in tissue engineering and regenerative
medicine. Our previous results have shown that the shish–kebab
structure-modified fibrous scaffold shows a completely different microenvironment
that mimics the topography of the collagen fibers, which interestingly
facilitates the cell adhesion and migration. However, the functionalization
of the unique structure needs to be further investigated. In this
study, we modified the heparin-loaded fiber with a shish–kebab
structure and tuned the kebab structure as the barrier for the sustained
release of heparin. The introduction of the kebab structure increases
the diffusion energy barrier by extending the diffusion distance.
Moreover, the discontinued surface topography of the shish–kebab
structure altered the surface chemistry from hydrophobic for the original
poly(ε-caprolactone) (PCL) nanofibers to hydrophilic for the
PCL nanofibers with the shish–kebab structure, which might
have inhibited the activation of fibrinogen and thus improved the
anticoagulant ability. This synergistic effect of heparin and the
kebab structure significantly promotes the endothelial cell affinity
and antithrombogenicity. This method might be a viable and versatile
drug delivery strategy in vascular tissue engineering.
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completely different microenvironmentunique structure needsendothelial cell affinitykebab structure increasesvascular tissue engineeringcontrolled drug releasediscontinued surface topographydiffusion energy barrierkebab structuretissue engineeringsurface chemistrydiffusion distancecell adhesionthus improvedsynergistic effectsustained releaseregenerative medicineprevious resultsloaded fiberinterestingly facilitatescollagen fibersanticoagulant ability