posted on 2023-10-12, 09:06authored byLi Xiong, Huan Wang, Junsu Wang, Jinyang Luo, Ruiqi Xie, Fei Lu, Guangqian Lan, Liang-Ju Ning, Rong Yin, Wenyi Wang, Enling Hu
Bioadhesives
have been widely used in hemostasis and tissue repair,
but the overmoist and wet nature of wound surface (due to the presence
of blood and/or wound exudate) has led to poor wet adhesion of bioadhesives,
which interrupts the continuous care of wounds. Here, a thirsty polyphenolic
silk granule (Tan@SF-pwd-hydro), which absorbs blood
and exudate to self-convert to robust bioadhesives (Tan@SF-gel-hydro) in situ, was facilely developed in this study
for enhanced wet adhesion toward hemostasis and tissue repair. Tan@SF-pwd-hydro could shield wounds’ wetness and
immediately convert itself to Tan@SF-gel-hydro to
seal wounds for hemorrhage control and wound healing. The maximum
adhesiveness of Tan@SF-gel-hydro over wet pigskin
was as high as 59.8 ± 2.1 kPa. Tan@SF-pwd-hydro is a promising transformative dressing for hemostasis and tissue
repair since its hemostatic time was approximately half of that of
the commercial hemostatic product, CeloxTM, and its healing
period was much shorter than that of the commercial bioadhesive product,
TegadermTM. This pioneering study utilized adverse wetness
over wounds to arouse robust adhesiveness by converting thirsty granules
to bioadhesives in situ, creatively turning adversity
into opportunities. The facile fabrication approach also offers new
perspectives for manufacturing sustainability of biomaterials.