nn2c04260_si_003.mp4 (15.47 MB)
Crack Sensing of Cardiomyocyte Contractility with High Sensitivity and Stability
mediaposted on 2022-07-22, 17:05 authored by Li Wang, Xingyuan Xu, Jun Chen, Weiguang Su, Feng Zhang, Anqing Li, Chao Li, Chonghai Xu, Yu Sun
Measuring myocardial contractility is of great value in exploring cardiac pathogenesis and quantifying drug efficacy. Among the biosensing platforms developed for detecting the weak contractility of a single layer of cardiomyocytes (CMs), thin brittle metal membrane sensors with microcracks are highly sensitive. However, their poor stability limits the application in long-term measurement. Here, we report a high stability crack sensor fabricated by deposition of a 105 nm thick Ag/Cr with microcracks onto a carbon nanotubes-polydimethylsiloxane (CNT-PDMS) layer. This brittle-tough bilayer crack sensor achieved high sensitivity (gauge factor: 108 241.7), a wide working range (0.01–44%), and high stability (stable period >2 000 000 cycles under the strain caused by a monolayer of CMs). During 14-day continuously monitoring CMs culturing and drug treatment testings, the device demonstrated high sensitivity and stability to record the dynamic change caused by contractility of the CMs.
wide working rangequantifying drug efficacyexploring cardiac pathogenesisdrug treatment testingsbiosensing platforms developeddynamic change causedpoor stability limitsstrain causedterm measurementstable periodhighly sensitivehigh stabilityhigh sensitivitygreat valuegauge factorcrack sensingcarbon nanotubes7 ),108 241