posted on 2023-06-16, 16:06authored byNan Li, Chenxing Huang, Jie Zhang, Junyue Zhang, Jia Huang, Shangshang Li, Xue Xia, Ziyu Wu, Chenglong Chen, Shuwan Tang, Xiangyu Xiao, Hui Gong, Yuxiang Dai, Chun Mao, Mimi Wan
Recombinant granulocyte colony-stimulating factor (G-CSF),
with
a direct repair effect on injured cardiomyocytes against myocardial
infarction ischemia-reperfusion-injury (IRI), displays a poor effect
owing to the limited cardiac targeting efficacy. There are almost
no reports of nanomaterials that deliver G-CSF to the IRI site. Herein,
we propose a way to protect G-CSF by constructing one layer of nitric
oxide (NO)/hydrogen sulfide (H2S) nanomotors on its outside.
NO/H2S nanomotors with specific chemotactic ability to
high expression of reactive oxygen species (ROS)/induced nitric oxide
synthase (iNOS) at the IRI site can deliver G-CSF to the IRI site
efficiently. Meanwhile, superoxide dismutase is covalently bound to
the outermost part, reducing ROS at the IRI site through a cascade
effect with NO/H2S nanomotors. The synergistic effect between
NO and H2S on the effective regulation of the IRI microenvironment
can not only avoid toxicity caused by excessive concentration of a
single gas but also reduce inflammation level and relieve calcium
overload, so as to promote G-CSF to play a cardioprotective role.