nn5b06939_si_002.avi (29.97 MB)
Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy
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posted on 2016-03-03, 00:00 authored by Hongzhao Qi, Chaoyong Liu, Lixia Long, Yu Ren, Shanshan Zhang, Xiaodan Chang, Xiaomin Qian, Huanhuan Jia, Jin Zhao, Jinjin Sun, Xin Hou, Xubo Yuan, Chunsheng KangExosomes are a class of naturally
occurring nanoparticles that
are secreted endogenously by mammalian cells. Clinical applications
for exosomes remain a challenge because of their unsuitable donors,
low scalability, and insufficient targeting ability. In this study,
we developed a dual-functional exosome-based superparamagnetic nanoparticle
cluster as a targeted drug delivery vehicle for cancer therapy. The
resulting exosome-based drug delivery vehicle exhibits superparamagnetic
behavior at room temperature, with a stronger response to an external
magnetic field than individual superparamagnetic nanoparticles. These
properties enable exosomes to be separated from the blood and to target
diseased cells. In vivo studies using murine hepatoma
22 subcutaneous cancer cells showed that drug-loaded exosome-based
vehicle delivery enhanced cancer targeting under an external magnetic
field and suppressed tumor growth. Our developments overcome major
barriers to the utility of exosomes for cancer application.