l‑(−)-Quebrachitol as a Ligand
for Selective Copper(0)-Catalyzed
N‑Arylation of Nitrogen-Containing Heterocycles

Zhou, Qifan; Du, Fangyu; Chen, Yuanguang; Fu, Yang; Sun, Wenjiao; Wu, Ying; Chen, Guoliang

doi:10.1021/acs.joc.9b00997.s001

l‑(−)-Quebrachitol as a Ligand for Selective Copper(0)-Catalyzed N‑Arylation of Nitrogen-Containing Heterocycles

journal contribution

posted on 2019-06-05, 00:00 authored by Qifan Zhou, Fangyu Du, Yuanguang Chen, Yang Fu, Wenjiao Sun, Ying Wu, Guoliang Chen

l-(−)-Quebrachitol (QCT) has been found as a ligand of copper powder for selective N-arylation of nitrogen-containing heterocycles with aryl halides. Furthermore, another potential catalytic system (copper powder/QCT/t-BuOK) was successfully adapted to unactivated aryl chlorides.

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Keywords

Ligand QCT BuOK copper powder ligand Heterocycle Quebrachitol Nitrogen-Containing aryl halides Selective nitrogen-containing heterocycles N-arylation unactivated aryl chlorides

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CC BY-NC 4.0

l‑(−)-Quebrachitol as a Ligand for Selective Copper(0)-Catalyzed N‑Arylation of Nitrogen-Containing Heterocycles

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