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68Ga-NODAGA-Indole: An Allysine-Reactive Positron Emission Tomography Probe for Molecular Imaging of Pulmonary Fibrogenesis

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journal contribution
posted on 25.03.2019, 00:00 by Jessica Wahsner, Pauline Désogère, Eric Abston, Katherine A. Graham-O’Regan, Junfeng Wang, Nicholas J. Rotile, Markus D. Schirmer, Diêgo Dos Santos Ferreira, Jingyi Sui, Bryan C. Fuchs, Michael Lanuti, Peter Caravan
Oxidized collagen, wherein lysine residues are converted to the aldehyde allysine, is a universal feature of fibrogenesis, i.e. actively progressive fibrosis. Here we report the small molecule, allysine-binding positron emission tomography probe, 68Ga-NODAGA-indole, that can noninvasively detect and quantify pulmonary fibrogenesis. We demonstrate that the uptake of 68Ga-NODAGA-indole in actively fibrotic lungs is 7-fold higher than in control groups and that uptake is linearly correlated (R2 = 0.98) with the concentration of lung allysine.