posted on 2021-10-09, 16:29authored byChang Guo, Qiangqiang Nie, Suying Xu, Leyu Wang
Dual-modal
imaging systems could provide complementary information
by taking advantage of each imaging modality. Herein, a fluorescence
and 19F magnetic resonance imaging nanoprobe was developed
through preparation of 19F-grafted fluorescent carbonized
polymer dots (FCPDs). Both fluorescence and 19F nuclear
magnetic resonance intensities of these FCPDs can be modulated by
controlling the carbonization processes. The strong yellow fluorescence
renders these FCPDs capable of cell fluorescence imaging. The in vitro
and in vivo assessments demonstrated that the as-prepared FCPDs were
suitable for 19F magnetic resonance imaging (19F MRI), which would provide great potential for biological imaging
and early diagnosis applications. Moreover, this fabrication strategy
offers a new protocol for 19F MRI nanoprobe design.