O‑Glycosylation Enabled by N-(Glycosyloxy)acetamides

A novel glycosylation protocol has been established by using N-(glycosyloxy)­acetamides as glycosyl donors. The N-oxyacetamide leaving group in donors could be rapidly activated in the presence of Cu­(OTf)₂ or SnCl₄ under microwave irradiation. This glycosylation process afforded the coupled products in high yields, and the reaction enjoyed a broad substrate scope, even for disarmed donors and hindered acceptors. The easy availability of the donors, the high stability of N-(glycosyloxy)­acetamides, and the small leaving group make this method very practical.