O-Alkenyl Hydroxylamines: A New Concept for Cyclofunctionalization
journal contributionposted on 06.11.2002, 00:00 by Roderick W. Bates, Kanicha Sa-Ei
Treatment of O-homoallylhydroxylamines with palladium(II) and copper(II) in the presence of a base, methanol, and carbon monoxide results in the formation of isooxazolidines. An electron-withdrawing group on the hydroxylamine nitrogen is essential. When carbamate groups are used the products are formed exclusively as their cis isomers.