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O-Alkenyl Hydroxylamines:  A New Concept for Cyclofunctionalization

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journal contribution
posted on 06.11.2002, 00:00 authored by Roderick W. Bates, Kanicha Sa-Ei
Treatment of O-homoallylhydroxylamines with palladium(II) and copper(II) in the presence of a base, methanol, and carbon monoxide results in the formation of isooxazolidines. An electron-withdrawing group on the hydroxylamine nitrogen is essential. When carbamate groups are used the products are formed exclusively as their cis isomers.