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Ketone-DNA:  A Versatile Postsynthetic DNA Decoration Platform

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journal contribution
posted on 17.11.2001, 00:00 by Subhakar Dey, Terry L. Sheppard
A general strategy for the functional diversification of DNA oligonucleotides under physiological conditions was developed. We describe the synthesis of DNA molecules bearing ketone ports (ketone-DNA) and the efficient postsynthetic decoration of ketone-DNA with structurally diverse aminooxy compounds.