American Chemical Society
ja7b11158_si_001.pdf (2.7 MB)

Ex Vivo Tracking of Endogenous CO with a Ruthenium(II) Complex

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Version 2 2019-07-01, 20:29
Version 1 2017-12-06, 18:26
journal contribution
posted on 2017-12-27, 00:00 authored by Cristina de la Torre, Anita Toscani, Cristina Marín-Hernández, Jonathan A. Robson, María Carmen Terencio, Andrew J. P. White, María José Alcaraz, James D. E. T. Wilton-Ely, Ramón Martínez-Máñez, Félix Sancenón
A two-photon fluorescent probe based on a ruthenium­(II) vinyl complex is capable of selectively detecting carbon monoxide in cells and ex vivo using mice with a subcutaneous air pouch as a model for inflammation. This probe combines highly selective and sensitive ex vivo detection of endogenous CO in a realistic model with facile, inexpensive synthesis, and displays many advantages over the widely used palladium-based systems.